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Diabetes 65(1):3443

In the studies of tirzepatide, for example, seniors on the drug were about twice as likely to stop taking their medication because of adverse events compared with younger adults and other older adults who were in the same study but got a placebo

Many patients also experience bloating, excessive gas (flatulence & belching), and heartburn

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Altogether, it appears that VEGF might have two roles in neuroprotection: as a direct neurotrophic agent and as an angiogenic factor stimulating endothelial cells to provide adequate perfusion and neurotrophic factors (Rosenstein et al., 2010)